Vinod Khanna's second wife, Kavita Khanna, has now disclosed that he was first diagnosed with lung cancer in 2001 as a result of his frequent smoking, according to previously unreported information. The actor lost his fight with bladder cancer in 2017. The late actor's wife also revealed that he was forcefully advised to avoid drinking following his diagnosis of bladder cancer.

Vinod Khanna's second wife reflected on her late husband's fight with cancer in a video posted to her YouTube channel. "It was 2001 when Vinod had a diagnosis of lung cancer. He’d gone for his annual checkup, and they saw patches in the lungs. He’d smoke 40 to 80 cigarettes a day. We went to the leading MRI specialists of Mumbai, and they all said it was lung cancer, said Kavita mentioned that the doctors informed them they would need to remove half of his lung."

Vinod Khanna and Kavita sought guidance from their spiritual mentor, Sri Sri Ravi Shankar, and made the decision to keep the diagnosis confidential before considering surgery. "Later, we went to Germany. One evening, Vinod got this terrible pain somewhere around his shoulder. He was just lying in pain for two days. Then Gurudev came to see how he was, and then suggested we get an X-ray done. There was no broken rib, but the important thing was there’s no cancer. Unbelievable!"

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Vinod then called Gurudev and said, 'I've lived a full life. And if my time to go has come, I’m ready to go. But I I don’t want to torture my body'. Gurudev invited him to perform the panchkarma at the ashram.  He was diagnosed with cancer, but it was eradicated two years later. When we scanned it in America, it was no longer there.

Vinod Khanna's wife went on to say that London doctors later found it difficult to believe the results, thinking there had been a mistake, but they verified that the lung cancer had not returned. The outlook for Vinod's 2010 bladder cancer diagnosis was that he had a 25% chance of survival after two years if he took advantage of allopathy's resources, according to Kavita.

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Vinod Khanna would have one or two glasses of alcohol every evening, according to Kavita, who also revealed that their spiritual guru had instructed him to give up alcohol. Kavita Khanna said, "He was still in very good health when it started declining. He finally died of bladder cancer."

Vinod Khanna, who was praised for his parts in movies like Mere Apne and Qurbani, died in 2017 at the age of 70. He was being treated at the HN Reliance Foundation Hospital in Mumbai for severe bladder cancer. Vinod Khanna appeared noticeably weak in a widely shared social media image before he passed away.